サル及びイヌにおける直腸体温計と比較した体温計測併用マイクロチップによる体温測定法の有用性の検討

• 西谷 春香

  （株）サンプラネット 筑波研開支援事業部安全性支援ユニット

• 水野 洋

  エーザイ（株） ＢＡ　高度バイオシグナル安全性評価部

• 円城寺 克也

  （株）サンプラネット 筑波研開支援事業部安全性支援ユニット

• 則武 健一

  （株）サンプラネット 筑波研開支援事業部安全性支援ユニット

書誌事項

タイトル別名

• Usefulness of a temperature-sensing microchip compared with traditional rectal thermometers in monkeys and dogs

抄録

【Introduction】We compared body temperature (BT) in non-rodents between a temperature-sensing microchip (IPTT-300, BMDS) and traditional rectal thermometer (RT) or telemetry devices. We also compared the BT changes in several implantation sites to seek the optimal implantation site for microchips. 【Methods】Microchips were implanted subcutaneously at 3 sites (chest, thigh, and interscapular region) in telemetered monkeys (4 males), and at 3 sites (chest, neck, and interscapular region) in dogs (2 males and 2 females). Animals were dosed intramuscularly with medetomidine (α2 adrenergic agonist) at 0.15 mg/kg (monkeys) and 0.2 mg/kg (dogs) , and BT was measured predose and at 15 min intervals postdose until recovery using the microchips, RT, and telemetry devices (monkeys only). 【Results】All three methods recorded decreases in BTs with medetomidine. In monkeys, The interscapular microchips BTs were similar to the rectal and telemetry temperatures, and other 2 sites were lower than them. In dogs, there were no clear differences in BTs in the 3 sites, and degree of changes in BT by microchips was similar to the RT. 【Conclusion】Microchips are useful tools for BT measurement. The advantage of microchips include that there are quick and less invasive compared to a RT. The best implantation site of microchips was interscapular subcutis in both dogs and monkeys.

収録刊行物

• 日本毒性学会学術年会

  日本毒性学会学術年会 47.1 (0), P-175-, 2020

  日本毒性学会

詳細情報

• CRID: 1390848647545002240
• NII論文ID: 130007898340
• DOI: 10.14869/toxpt.47.1.0_p-175
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可