Investigation of HLA allotype-specific skin toxicity by abacavir using HLA transgenic mice

DOI
  • YAMADA Yushiro
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • AOKI Shigeki
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • FUJIMORI Sota
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • ITO Kousei
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University

Bibliographic Information

Other Title
  • HLA遺伝子導入マウスを用いたアバカビルによるHLA多型依存的な皮膚毒性発症機構の検討

Abstract

<p>[Aim] We investigated drug reactions in keratinocytes (KCs) by focusing on the interaction between HLA-B*57:01 and abacavir (ABC) using our originally produced HLA-B*57:01 transgenic mice (B*57:01-Tg).</p><p>[Results] ABC exposure increased mRNA expression of IFN-γ and immunoproteasome (IP) subunits induced by IFN-γ in KCs derived from B*57:01-Tg. In addition, ABC exposure increased protein expression of IP subunits in skin tissue of B*57:01-Tg. These results imply that increased IP expression by ABC exposure in KCs expressing HLA-B*57:01 might produce specific antigens and induce immunotoxicity.</p>

Journal

Details 詳細情報について

  • CRID
    1390004222614884224
  • NII Article ID
    130007898350
  • DOI
    10.14869/toxpt.47.1.0_p-62s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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