Suppressive mechanism of cold compress on cytotoxicity induced by mitomycin C

• TAKAISHI Masaki

  Department of Pharmaceutical Sciences, International University of Health and Welfare

• SASAKI Megumi

  Department of Pharmaceutical Sciences, International University of Health and Welfare

• HIRAGA Tatsuru

  Department of Pharmaceutical Sciences, International University of Health and Welfare

• SATO Kana

  Department of Pharmaceutical Sciences, International University of Health and Welfare

• TAKEDA Toshiaki

  Faculty of Nursing, Iwate Prefectural University

• ASANO Satoshi

  Department of Pharmaceutical Sciences, International University of Health and Welfare

Bibliographic Information

Other Title

• マイトマイシンCの細胞傷害に対する冷罨法の抑制メカニズム

Abstract

In this study, we examined the inhibitory effect of cold compress on cytotoxicity of MMC using apoptosis and oxidative stress as an indicator. In the cells exposed to MMC at 37°C, that caused apoptosis significantly increased from 24 hours after exposure. On the other hand, cells exposed to MMC at 23°C did not caused apoptosis. Only cells exposed to MMC at 37°C, the intracellular malondialdehyde concentration significantly increased. Therefore, apoptosis and oxidative stress were observed in the cytotoxicity caused by MMC, and it was clarified that the cold compress suppressed these.

Journal

• Annual Meeting of the Japanese Society of Toxicology

  Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-99-, 2020

  The Japanese Society of Toxicology

Details

• CRID: 1390848647545182592
• NII Article ID: 130007898516
• DOI: 10.14869/toxpt.47.1.0_p-99
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed