Effects of four atypical antipsychotics on autonomic nervous system activity in schizophrenia

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  • Hattori Saki
    Department of Psychiatry, Yokohama City University School of Medicine, Japan
  • Suda Akira
    Department of Psychiatry, Yokohama City University School of Medicine, Japan
  • Kishida Ikuko
    Department of Psychiatry, Yokohama City University School of Medicine, Japan Fujisawa Hospital, Japan
  • Miyauchi Masatoshi
    Department of Psychiatry, Yokohama City University School of Medicine, Japan
  • Fujibayashi Mami
    Division of Physical and Health Education, Setsunan University, Japan
  • Tsujita Natsuki
    Graduate School of Human and Environmental Studies, Kyoto University, Japan
  • Ishii Chie
    Fujisawa Hospital, Japan
  • Ishii Norio
    Fujisawa Hospital, Japan
  • Moritani Toshio
    Faculty of General Education, Kyoto Sangyo University, Japan
  • Hirayasu Yoshio
    Department of Psychiatry, Yokohama City University School of Medicine, Japan

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<p>Antipsychotic drugs are associated with autonomic nervous system (ANS) dysfunction in patients with schizophrenia, but the effects of individual atypical antipsychotic drugs are not clear. This study investigated how four atypical antipsychotic drugs -risperidone, olanzapine, quetiapine, and aripiprazole- differ in their effects on ANS activity. A total of 241 Japanese patients with schizophrenia participated in this study. All of the participants received an atypical antipsychotic as monotherapy: 90 participants received risperidone, 68 olanzapine, 52 aripiprazole, and 31 quetiapine. ANS activity was assessed by means of a power spectral analysis of heart rate variability. The quetiapine group showed significantly diminished sympathetic and parasympathetic activity compared with the risperidone and aripiprazole groups and significantly lower sympathetic activity relative to olanzapine. In addition, multiple regression analysis showed that the type of antipsychotic drug significantly influenced ANS activity. We suggest that, among the antipsychotics examined-risperidone, olanzapine, quetiapine, and aripiprazole-quetiapine has the strongest effect on ANS activity.</p>

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