Clinicopathological study of pT1/T2 tongue squamous cell carcinoma: Correlation between its invasive pattern and prognosis

• Henmi Takuo

  Division of Oral Diagnosis, Oral and Maxillofacial Radiology and Pathology Diagnostic Services, The Nippon Dental University Hospital

• Machida Tomomasa

  Department of Oral Surgery, Sainokuni Higashiomiya Medical Center

• Takeda Munenori

  Oral and Maxillofacial Surgery, The Nippon Dental University Hospital

• Kitazume Eri

  Oral and Maxillofacial Surgery, The Nippon Dental University Hospital

• Inomata Toru

  Oral and Maxillofacial Surgery, The Nippon Dental University Hospital

• Ishigaki Yoshiki

  Oral and Maxillofacial Surgery, The Nippon Dental University Hospital

• Shoji Hirobumi

  Oral and Maxillofacial Surgery, The Nippon Dental University Hospital

• Soeno Yuuichi

  Department of Pathology, School of Life Dentistry at Tokyo, The Nippon Dental University

• Izumo Toshiyuki

  Division of Oral Diagnosis, Oral and Maxillofacial Radiology and Pathology Diagnostic Services, The Nippon Dental University Hospital

• Yagishita Hisao

  Division of Oral Diagnosis, Oral and Maxillofacial Radiology and Pathology Diagnostic Services, The Nippon Dental University Hospital

Bibliographic Information

Other Title

• pT1/T2舌扁平上皮癌における浸潤様式分類と予後に関する臨床病理学的検討

Abstract

In routine pathological diagnoses of oral squamous cell carcinoma （SCC）, histopathological factors such as invasive pattern are assessed to determine the prognosis. In Japan, the Yamamoto–Kohama （YK） classification is generally used. The pattern of infiltrating growth （INF） and tumor budding are recently used as well. Moreover, the AJCC cancer staging manual （8th edition） now lists the worst pattern of invasion （WPOI）-5 as a validated outcome predictor for oral cancer. In this study, we investigated the characteristics of the YK classification, INF, tumor budding, and WPOI-5 with respect to their usefulness as prognostic indicators for pT1/T2 tongue SCC. Three oral pathologists evaluated invasive patterns independently. The individual SCC cases classified as YK-4C, INFc, tumor budding ＞5, or WPOI-5 showed high lymph node metastatic rate and low survival rate, related to increasing risks of poor prognosis. Additionally, the prognoses among these four groups showed no statistical differences, therefore the usefulness of these patterns as prognostic indicators is likely to be equivalent. Cross tabulation indicated that the YK classification, INF, and tumor budding were mutually correlated, and that WPOI-5 might be a histopathological factor that differed from the other three criteria. By simultaneous assessment of these four criteria in each SCC case, we found that most cases met multiple criteria of YK-4C, INFc, tumor budding ＞5, and WPOI-5. Therefore, we concluded that it is effective to apply multiple invasive patterns, specifically the combined use of WPOI-5 and another criterion, to more accurately predict the prognosis of pT1/T2 tongue SCC.

Journal

• Journal of Japanese Society of Oral Oncology

  Journal of Japanese Society of Oral Oncology 32 (3), 63-70, 2020

  Japanese Society of Oral Oncology

Keywords

• tongue squamous cell carcinoma
• invasive pattern
• clinicopathological study

Details

• CRID: 1390285697597821696
• NII Article ID: 130007906556
• DOI: 10.5843/jsot.32.63
• ISSN: 18844995
• ISSN: 09155988
• Web Site: https://www.jstage.jst.go.jp/article/jsot/32/3/32_63/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed