Intracellular Organelles Driven by Liquid-Liquid Phase Separation

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  • SHIMOBAYASHI Shunsuke F.
    Department of Chemical & Biological Engineering, Princeton University
  • OHSAKI Yuki
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine

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  • 液液相分離が駆動する細胞内オルガネラ
  • エキ エキソウ ブンリ ガ クドウ スル サイボウ ナイ オルガネラ

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Abstract

<p>Recently, there is growing evidence in the field of cell biology that membrane-less organelles or condensates are formed by liquid-liquid phase separation (LLPS), as well as some types of membrane-bound organelles like lipid rafts and lipid droplets. Biophysical analyses are powerful and indispensable to elucidate those structures, dynamics and (dys)functions. Here, we combine in vivo intracellular imaging with in vitro synthetic biology and soft-matter physics, to show a new avenue for understanding the biophysics of LLPS-driven organelles. In this review, we particularly discuss macro-to-micro phase separation in lipid rafts and liquid-liquid crystal phase transition in lipid droplets.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 60 (5), 267-271, 2020

    The Biophysical Society of Japan General Incorporated Association

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