T型カルシウムチャネルによる神経機能調節機構の解明

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  • 矢吹 悌
    東北大学大学院薬学研究科薬理学分野

書誌事項

タイトル別名
  • Role of T-type Calcium Channels in Regulating Neuronal Function
  • Review for award T型カルシウムチャネルによる神経機能調節機構の解明
  • Review for award Tガタ カルシウムチャネル ニ ヨル シンケイ キノウ チョウセツ キコウ ノ カイメイ

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<p>T-type calcium channels are low-threshold voltage-gated calcium channel and characterized by unique electrophysiological properties such as fast inactivation and slow deactivation kinetics. All subtypes of T-type calcium channel (Cav3.1, 3.2 and 3.3) are widely expressed in the central nerve system, and they have an important role in homeostasis of sleep, pain response, and development of epilepsy. Recently, several reports suggest that T-type calcium channels may mediate neuronal plasticity in the mouse brain. We succeeded to develop T-type calcium channel enhancer ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopentane-1,3′-imidazo[1,2-a]pyridine]-2-ene-3-carboxylate (SAK3) which enhances Cav3.1 and 3.3 currents in each-channel expressed neuro2A cells. SAK3 can promote acetylcholine (ACh) release in the mouse hippocampus via enhancing T-type calcium channel. In this review, we have introduced the role of T-type calcium channel, especially Cav3.1 channel in the mouse hippocampus based on our previous data using SAK3 and Cav3.1 knockout mice.</p>

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  • 薬学雑誌

    薬学雑誌 140 (10), 1207-1212, 2020-10-01

    公益社団法人 日本薬学会

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