Relapse of psychiatric symptoms after discontinuation of antipsychotics in pregnant women with schizophrenia: a retrospective study

• Seki Ryota

  Department of Psychiatry, Graduate School of Medicine, Chiba University

• Hashimoto Tasuku

  Department of Psychiatry, Graduate School of Medicine, Chiba University Department of Psychiatry, School of Medicine, International University of Health and Welfare

• Tanaka Mami

  Division of Clinical Study on Juvenile Delinquency, Center for Forensic Mental Health, Chiba University

• Sato Aiko

  Department of Psychiatry, Graduate School of Medicine, Chiba University Department of Psychiatry, School of Medicine, International University of Health and Welfare

• Kimura Hiroshi

  Department of Psychiatry, School of Medicine, International University of Health and Welfare

• Kimura Atsushi

  Department of Psychiatry, Graduate School of Medicine, Chiba University

• Handa Satoshi

  Department of Psychiatry, School of Medicine, International University of Health and Welfare

• Kanahara Nobuhisa

  Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health

• Okayama Jun

  Department of Maternal-Fetal Medicine, Chiba University Hospital

• Omoto Akiko

  Department of Maternal-Fetal Medicine, Chiba University Hospital

• Endo Mamiko

  Department of Pediatrics, Chiba University Graduate School of Medicine

• Osone Yoshiteru

  Department of Pediatrics, Chiba University Graduate School of Medicine

• Watanabe Hiroyuki

  Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health Department of Psychiatry, Gakuji-kai Kimura Hospital

• Tanaka Hirokazu

  Department of Obstetrics and Gynecology, School of Medicine, International University of Health and Welfare

• Nakazato Michiko

  Department of Psychiatry, School of Medicine, International University of Health and Welfare

• Shozu Makio

  Department of Reproductive Medicine, Graduate School of Medicine, Chiba University

• Iyo Masaomi

  Department of Psychiatry, Graduate School of Medicine, Chiba University

Abstract

This study aimed to examine the effect of discontinuation of antipsychotic medication on the relapse of psychiatric symptoms in pregnant women with schizophrenia. We investigated the medical records of all consecutive pregnant women with schizophrenia who continuously visited and delivered their children at Chiba University Hospital from January 2007 to January 2019. We retrospectively assessed the scores on the Clinical Global Impression of Change scale (CGI-C) during the period when psychiatric symptoms changed most during the pregnancy. A CGI-C score of 5 or more was defined as a relapse. Twenty-eight patients consisting of the maintained treatment group (n = 18) and the discontinuation group (n= 10) were recruited. During pregnancy, the relapse rate in the maintained treatment group (16.7%) was significantly lower than that in the discontinuation group (90.0%). This study demonstrates a high relapse rate in pregnant women discontinuing their antipsychotic medication, as well as during the non-pregnancy period.

Journal

• Clinical Neuropsychopharmacology and Therapeutics

  Clinical Neuropsychopharmacology and Therapeutics 11 (0), 61-66, 2020-10-02

  The Japanese Society of Clinical Neuropsychopharmacology

Keywords

• antipsychotics
• pregnancy
• relapse
• schizophrenia

Details

• CRID: 1390285697607821312
• NII Article ID: 130007921985
• DOI: 10.5234/cnpt.11.61
• ISSN: 18848826
• Web Site: https://www.jstage.jst.go.jp/article/cnpt/11/0/11_61/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021266416
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed