Synthesis and Dilute Solution Properties of <i>N</i>-(2-Hydroxypropyl) methacrylamide-Based Copolymers

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  • Doi Kiyomasa
    The Faculty of Environmental Engineering, The University of Kitakyushu
  • Takahashi Rintaro
    Institute of Environmental Science and Technology, The University of Kitakyushu
  • Fujii Shota
    Institute of Environmental Science and Technology, The University of Kitakyushu
  • Sakurai Kazuo
    Institute of Environmental Science and Technology, The University of Kitakyushu

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Other Title
  • 2－ヒドロキシプロピルメタクリルアミド系共重合体の合成と溶液物性

Abstract

<p>Poly[N-(2-Hydroxypropyl)methacrylamide] (PHPMA) shows excellent biocompatibility and thus is expected to be used as a carrier in a drug delivery system. In this study, we investigated how the difference in the monomer structure influences the sequence in copolymers composed of HPMA and monomers (MA-ahNHNH-Boc and MA-NHNH-Boc); the size of MA-ah-NHNH-Boc is larger than that of MA-NHNH-Boc by the alkyl chain (CH2)5 spacer. Because the obtained copolymers showed a phase separation behavior upon heating,we also investigated this phase separation behavior by turbidimetry and the molecular dimension in dilute aqueous solution by small-angle X-ray scattering (SAXS). Consequently, we found that the difference between the monomers (MA-ah-NHNH-Boc or MA-NHNH-Boc) significantly influences the monomer sequence in copolymer chains, the cloud point temperature, and the chain dimension in aqueous solution.</p>

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