Evaluation of the Prevalence and Risk Factors for Osteoradionecrosis of the Jaw in Patients Treated with Intensity-modulated Radiation Therapy

• Kudoh Takaharu

  Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School

• Takahashi Akira

  Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School

• Kudoh Keiko

  Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School

• Miyamoto Youji

  Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School

Bibliographic Information

Other Title

• 強度変調放射線治療に伴う放射線性顎骨壊死の頻度と危険因子の検討

Abstract

This study aimed to estimate the prevalence and determine the risk factors for the development of osteoradionecrosis （ORN） of the jaw after intensity-modulated radiation therapy （IMRT）. The cases of 114 patients who achieved complete remission after undergoing IMRT for head and neck cancer between 2011 and 2017 were retrospectively reviewed. The treatment involved IMRT with simultaneous integrated boost. The maximum dose delivered to the mandible and the mean dose delivered to the maxillae were kept below 70Gy and 35Gy, respectively. Age, sex, disease stage, the intent of radiation therapy, the maximum dose delivered to the jaw, whether the patient was dentulous or edentulous, the presence/absence of chemotherapy, diabetes mellitus, and smoking history were evaluated as risk factors for ORN. ORN was observed in 3 maxillae and 4 mandibles, and a total of 7 （6.1%） patients developed ORN during a median follow-up period of 15 months （6-28 months）. The maximum dose delivered to the jaw （70Gy） was significantly related to the development of ORN of the jaw. No other significant factors were identified. As ORN was observed in 3maxillae, we should consider dose constraints for both the mandible and maxillae to prevent ORN of the jaw.

Journal

• Shika Hoshasen

  Shika Hoshasen 60 (1), 17-20, 2020

  Japanese Society for Oral and Maxillofacial Radiology

Keywords

• Osteoradionecrosis of jaw
• Intensity-modulated radiation therapy
• Maximum dose

Details

• CRID: 1390004222631414144
• NII Article ID: 130007922437
• NII Book ID: AN00101479
• DOI: 10.11242/dentalradiology.60.17
• ISSN: 21856311
• ISSN: 03899705
• Web Site: http://repo.lib.tokushima-u.ac.jp/115355
• Web Site: https://search.jamas.or.jp/link/ui/2021033282
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed