A case of Neurofibromatosis type 1 with tongue neurofibroma and Gastrointestinal stromal tumor (GIST)
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- MASUI Atsushi
- Department of Oral and Maxillofacial Surgery, Itami City Hospital
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- OTA Yoshiyuki
- Department of Oral and Maxillofacial Surgery, Itami City Hospital
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- KIM Yongmoon
- Department of Oral and Maxillofacial Surgery, Itami City Hospital
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- IMAI Tomoaki
- Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
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- UZAWA Narikazu
- Department of Oral and Maxillofacial Surgery Ⅱ, Osaka University Graduate School of Dentistry
Bibliographic Information
- Other Title
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- 舌神経線維腫と消化管間質腫瘍(GIST)が併存した神経線維腫症1型の1例
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Abstract
Neurofibromatosis type 1 (NF1) has been known as von Recklinghausen’s disease. NF1 is an autosomal dominant disease with café-au-lait spots and neurofibromas on the skin and various symptoms of the nerves, bones, eyes, and so on. Gastrointestinal stromal tumor (GIST) is generally defined as a mesenchymal tumor from interstitial cells of Cajal. NF1 is the most common genetic syndrome associated with developing GIST. We describe a case of both GIST and tongue neurofibroma found to be associated with NF1. A 63-year-old woman was referred for preoperative oral examination of GIST. She had noticed a tongue mass several years earlier, but had not felt any pain or problem in her daily life. Histopathological examination showed that both GIST and tongue neurofibroma had no characteristic finding associated with NF1. She turned out to be NF1 from postoperative interviews and general findings.<br>In this case, it was not the tongue neurofibroma that resulted in a diagnosis of NF1; this is important because the recurrence rate and complications may differ depending on whether GIST is associated with NF1. A greater awareness of NF1-related diseases such as GIST would lead to more accurate preoperative diagnosis and treatment of oral lesions.
Journal
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- Journal of The Japanese Stomatological Society
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Journal of The Japanese Stomatological Society 69 (3), 221-226, 2020
Japanese Stomatological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390004222633784192
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- NII Article ID
- 130007924706
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- ISSN
- 21850461
- 00290297
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed