Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: the Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody
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- Arai Toru
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Kasai Takahiko
- Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Shimizu Kazunori
- Department of Pulmonary Critical Care Medicine, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Japan
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- Kawahara Kunimitsu
- Department of Pathology, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, Japan
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- Katayama Kanako
- Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Sugimoto Chikatoshi
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Hirose Masaki
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Okamoto Hiroyuki
- Department of Dermatology, Kansai Medical University, Japan
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- Tachibana Kazunobu
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Akira Masanori
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Inoue Yoshikazu
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Abstract
<p>Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction due to anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. We experienced 2 cases of APAP complicated with sarcoidosis in a 42-year-old woman and a 51-year-old man (age at the sarcoidosis diagnosis). APAP preceded sarcoidosis in the woman, and both diseases were diagnosed simultaneously in the man. Sarcoidosis lesions were observed in the lung, skin, and eyes, and the pathological findings of APAP were not marked at the diagnosis of sarcoidosis in either case. Low-grade positive serum anti-GM-CSF autoantibody was suspected to be correlated with the occurrence of sarcoidosis and resolution of APAP. </p>
Journal
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- Internal Medicine
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Internal Medicine 59 (20), 2539-2546, 2020-10-15
The Japanese Society of Internal Medicine