'Quality' of Schizophrenia-relevant Molecules: from Genetic and Environmental Factors to Proteins

DOI Web Site Web Site 3 References Open Access
  • TOYOSHIMA Manabu
    Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science
  • JIANG Xuguang
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo
  • OGAWA Tadayuki
    Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo
  • HIROKAWA Nobutaka
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo
  • YOSHIKAWA Takeo
    Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science

Bibliographic Information

Other Title
  • 統合失調症に関連する分子の「質」: 遺伝子・環境因子からタンパク質まで
  • 分析化学総説 統合失調症に関連する分子の「質」 : 遺伝子・環境因子からタンパク質まで
  • ブンセキ カガク ソウセツ トウゴウ シッチョウショウ ニ カンレン スル ブンシ ノ 「 シツ 」 : イデンシ ・ カンキョウ インシ カラ タンパクシツ マデ

Search this article

Abstract

<p>Schizophrenia is a debilitating psychiatric disorder, with a prevalence of approximately 1 % worldwide. The symptoms of schizophrenia include hallucinations and delusion (positive symptoms), apathy and withdrawal (negative symptoms), and cognitive impairments, which lead to disabilities in social and occupational functioning, and self-care. Although genetic elements have been extensively studied, the precise molecular mechanism of schizophrenia remains elusive. Recently, a role of reduced protein quality (protein aggregation) due to oxidative stress (carbonyl stress) and endoplasmic reticulum stress was proposed in the pathogenesis and pathology of schizophrenia. Here we explain the a current status of the research of schizophrenia while focusing on protein quality.</p>

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 69 (10.11), 531-537, 2020-10-05

    The Japan Society for Analytical Chemistry

References(3)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top