Frequency of Adverse Drug Reactions and Analgesic Effects of Mirogabalin during Treatment of Peripheral Neuropathic Pain: A Retrospective Clinical Investigation

• Inage Kazuhide

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Sainoh Takeshi

  Department of Orthopaedic Surgery, Sainou Hospital

• Fujiyoshi Takayuki

  Department of Orthopaedic Surgery, Kimitsu Chuo Hospital

• Otagiri Takuma

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Aoki Yasuchika

  Department of Orthopaedic Surgery, Eastern Chiba Medical Center

• Inoue Masahiro

  Department of Orthopaedic Surgery, Eastern Chiba Medical Center

• Eguchi Yawara

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Orita Sumihisa

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Shiga Yasuhiro

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Koda Masao

  Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba

• Akazawa Tsutomu

  Department of Orthopaedic Surgery, St. Marianna University School of Medicine

• Furuya Takeo

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Nakamura Junichi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Takahashi Hiroshi

  Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba

• Suzuki Miyako

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Maki Satoshi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Kinoshita Hideyuki

  Department of Orthopaedic Surgery, Chiba Cancer Center

• Norimoto Masaki

  Department of Orthopaedic Surgery, Toho University Sakura Medical Center

• Umimura Tomotaka

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Sato Takashi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Sato Masashi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Suzuki Masahiro

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Enomoto Keigo

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Takaoka Hiromitsu

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Mizuki Norichika

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Hozumi Takashi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Tsuchiya Ryuto

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Kim Geundong

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Mukaihata Tomohito

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Hishiya Takahisa

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

• Ohtori Seiji

  Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University

抄録

Introduction: Mirogabalin should be equivalent to pregabalin, but with fewer incidences of adverse drug reactions (ADRs). To verify these benefits in actual clinical trials, our study investigated the frequency of ADRs and mirogabalin's analgesic effects during treatment of peripheral neuropathic pain. Methods: This study included 74 patients with lower limb pain. We surveyed patient reports of ADRs during the follow-up period as the primary endpoint and examined the visual analog scale (VAS) reported for lower limb pain as the secondary endpoint (before administration, and two and four weeks after administration). Results: The occurrence of ADR was 27.0%, like the frequency of ADRs in the clinical trials for other disorders. However, the discontinuation rate of administration was 10.8%, which was significantly lower than the frequency of ADR occurrences. When the analgesic effect was assessed, a significant decrease in the temporal change of VAS for lower limb pain was observed before administration, and two and four weeks after administration. Conclusions: In this study, the occurrence of ADRs reported by the patients was like the frequency of ADRs reported in the clinical trials for other disorders. When assessing the analgesic effect, the temporal change of VAS for lower limb pain was found to decrease significantly before administration, and two and four weeks after administration.

収録刊行物

• Spine Surgery and Related Research

  Spine Surgery and Related Research 4 (4), 354-357, 2020-10-27

  一般社団法人 日本脊椎脊髄病学会

キーワード

• Mirogabalin
• neuropathic pain
• adverse drug reactions

詳細情報

• CRID: 1391975276382471936
• NII論文ID: 130007930893
• DOI: 10.22603/ssrr.2020-0042
• ISSN: 2432261X
• Web Site: https://www.jstage.jst.go.jp/article/ssrr/4/4/4_2020-0042/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021210226
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可