Functional analysis of mycobacterial protein PE_PGRS

DOI Open Access
  • Matsumura Kazunori
    Department of Diseases Control, Research Institute, National Center for Global Health and Medicine
  • Iwai Hiroki
    Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine
  • Kirikae Teruo
    Department of Microbiology, Juntendo University School of Medicine

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  • 結核菌タンパク質PE_PGRSの機能解析

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Abstract

<p> Tuberculosis (TB) remains an important infectious disease, causing ten million new cases and 1.4 million deaths a year in worldwide. Elucidating pathogenicity of Mycobacterium tuberculosis, the causative agent of TB, will contribute to development of new drugs, vaccines and treatments. Proline-glutamic acid (PE) /proline-proline-glutamic acid (PPE) family accounts for approximately 10% of the coding region of M. tuberculosis genome and its functions are largely unknown. PE proteins having polymorphic GC-rich repetitive sequences (PGRS) in carboxyl-terminal are members of PE_PGRS family. PE_PGRS62 and PE_PGRS30 are members of PE_PGRS family and homologues of MAG24, the virulence factor of M. marinum. We are in the process of analyzing the functions of PE_PGRS62 and PE_PGRS30, and have results suggesting that PE_PGRS62 regulates autophagy, whereas PE_PGRS30 induces cell death.</p>

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