Computational Study on the Synergic Effect of Brønsted Acid and Hydrogen-Bonding Catalysis for the Dearomatization Reaction of Phenols with Diazo Functionality
-
- Yanagawa Mai
- Graduate School of Pharmaceutical Sciences, Chiba University
-
- Kobayashi Mayu
- Graduate School of Pharmaceutical Sciences, Chiba University
-
- Ikeda Mitsuru
- Graduate School of Pharmaceutical Sciences, Chiba University
-
- Harada Shingo
- Graduate School of Pharmaceutical Sciences, Chiba University
-
- Nemoto Tetsuhiro
- Graduate School of Pharmaceutical Sciences, Chiba University Molecular Chirality Research Center, Chiba University
この論文をさがす
抄録
<p>Catalytic dearomative transformations of phenol variants via an ipso-Friedel-Crafts reaction could provide a straightforward method for the rapid assembly of functionalized spiromolecules as versatile synthetic scaffolds. We previously reported a dearomative spirocyclization reaction by merging Brønsted acid and hydrogen-bonding catalysis. However, it was unclear how the reaction proceeded and how the synergic effect was triggered. Described herein are the computational studies used to elucidate the reaction mechanism. Such calculations indicated that the applied catalysts, maleic acid and Schreiner’s thiourea, work cooperatively. The synergic effect enabled the chemoselectivity to interconvert between phenol dearomatization and O–H insertion, which is a major side reaction. This investigation also revealed that not only does the Schreiner’s thiourea catalyst serve as a hydrogen bonding donor, but the sulfur atom in thiourea possesses a general base function. The dual functional support of the thiourea along with maleic acid would thus realize the chemoselective prioritization of dearomatization over the O–H insertion reaction under mild conditions.</p>
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 68 (11), 1104-1108, 2020-11-01
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1391130851443025152
-
- NII論文ID
- 130007933572
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 030716051
-
- PubMed
- 33132378
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可