Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats

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  • Tani Mariko
    Graduate School of Human Science and Environment, University of Hyogo
  • Tanaka Sarasa
    Graduate School of Human Science and Environment, University of Hyogo
  • Takamiya Kana
    School of Human Science and Environment, University of Hyogo
  • Kato Yoji
    Graduate School of Human Science and Environment, University of Hyogo
  • Harata Gaku
    Technical Research Laboratory, Takanashi Milk Products Co., Ltd.
  • He Fang
    Technical Research Laboratory, Takanashi Milk Products Co., Ltd.
  • Sakaue Motoyoshi
    Graduate School of Human Science and Environment, University of Hyogo
  • Ito Mikiko
    Graduate School of Human Science and Environment, University of Hyogo

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Abstract

<p>Vascular calcification progresses under hyperphosphatemia, and represents a risk factor for cardiovascular disease in chronic kidney disease (CKD) patients. We recently indicated that phosphorus (P) fluctuations also exacerbated vascular calcification in early-stage CKD rats. Dietary fiber intake is reportedly associated with cardiovascular risk. This study investigated the effects of dietary fiber on vascular calcification by repeated P fluctuations in early-stage CKD rats. Unilateral nephrectomy rats were used as an early-stage CKD model. For 36 days, a P fluctuation (LH) group was fed low-P (0.02% P) and high-P (1.2% P) diets alternating every 2 days, and a P fluctuation with dietary fiber intake (LH + F) group was fed low-P and high-P diets containing dietary fiber alternating every 2 days. The effect on vascular calcification was measured calcium content. Effects on uremic toxin were measured levels of indoxyl sulfate (IS) and investigated gut microbiota. The LH + F group showed significantly reduced vessel calcium content compared to the LH group. Further, dietary fiber inhibited increases in blood levels of IS after intake of high-P diet, and decreased uremic toxin-producing intestinal bacteria. Dietary fiber may help suppress progression of vascular calcification due to repeated P fluctuations in early-stage CKD rats by decreasing uremic toxin-producing intestinal bacteria.</p>

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