Thioredoxin as a novel sensitive marker of biological stress response in smoking

• Soyama Tomonori

  Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University

• Masutani Hiroshi

  Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University Health Care Education and Research Center, Faculty of Health Care, Tenri Health Care University

• Lumi Hirata Cristiane

  Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University

• Iwai-Kanai Eri

  Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University Health Care Education and Research Center, Faculty of Health Care, Tenri Health Care University

• Inamoto Takashi

  Health Care Education and Research Center, Faculty of Health Care, Tenri Health Care University

抄録

Thioredoxin is a low molecular weight (approximately 12 kDa) redox protein, and protects against harmful stimuli such as oxidative stress. Smoking evokes oxidative stress, among other biological responses. The clinical relevance of thioredoxin in smoking has not been fully investigated. Here, we examined the effects of smoking on serum and urinary thioredoxin levels, in comparison with various stress markers. Serum thioredoxin levels in the smoking group (10 subjects) were significantly higher than those of the non-smoking group (5 subjects). After smoking, serum thioredoxin levels significantly decreased, while urinary levels significantly increased. On the other hand, the levels of serum and salivary cortisol, plasma norepinephrine, salivary amylase, salivary thioredoxin, and urinary 8-hydroxy-2'-deoxyguanosine levels before and after smoking were not significantly different. These results suggest that a decrease in thioredoxin in the serum and the concomitant increase in the urine is a novel sensitive marker of biological stress responses induced by smoking. The change seems to be evoked by mechanisms different from hormonal or 8-hydroxy-2'-deoxyguanosine-forming stress responses.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 67 (3), 228-231, 2020

  一般社団法人　日本酸化ストレス学会

キーワード

• smoking
• thioredoxin
• 8-OHdG
• oxidative stress
• stress marker

詳細情報

• CRID: 1391693801398547328
• NII論文ID: 130007934181
• DOI: 10.3164/jcbn.19-108
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/67/3/67_19-108/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021248538
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
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