Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle
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- Otomo Maki
- Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima, Japan
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- Harada Masafumi
- Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima, Japan
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- Abe Takashi
- Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima, Japan
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- Matsumoto Yuki
- Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima, Japan
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- Abe Yumi
- Department of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima, Japan
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- Kanazawa Yuki
- Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
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- Miyoshi Mitsuharu
- GE Healthcare, Tokyo, Japan
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- Kabasawa Hiroyuki
- GE Healthcare, Tokyo, Japan
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- Takahashi Yoshitake
- FUJIFILM Toyama Chemical, Tokyo, Japan
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Abstract
<p>Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion. J. Med. Invest. 67 : 321-327, August, 2020</p>
Journal
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 67 (3.4), 321-327, 2020
The University of Tokushima Faculty of Medicine