Design and Creation of Functional Membrane-Interacting Peptides

• Futaki Shiroh

  Institute for Chemical Research, Kyoto University

Abstract

Peptides provide a unique platform for creation of biofunctional molecules. Peptide design can be motivated by natural protein structures or attained de novo. For designed peptides to exert expected functions, a specific structure is needed whereby membranes can be employed to obtain stabilized helical structures. In biological systems, membranes are not limited to simple barriers between the extracellular and intracellular spaces or barriers that delineate intracellular compartments; they also stabilize the structures of peptides and proteins. Here, we review our approaches to the creation of membrane-interacting amphiphilic peptides as artificial ligand-gated ion channels, enhancers of cellular uptake of bioactive materials, and modulators of membrane lipid packing.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 78 (11), 1058-1065, 2020-11-01

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• Organic Chemistry

Details

• CRID: 1390286426511546752
• NII Article ID: 130007937276
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.78.1058
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 030772378
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030772378
• Web Site: https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/78/11/78_1058/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed