Roles of Transcription Factors and Signaling Networks in the Regulation of Lymphatic Endothelial Cell Function

• Yoshimatsu Yasuhiro

  Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)

• Watabe Tetsuro

  Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)

Bibliographic Information

Other Title

• リンパ管内皮細胞の機能制御における転写因子・シグナルネットワークの役割

Abstract

The homeobox transcription factor Prox1 is considered as a master regulator for the differentiation and function of lymphatic endothelial cells. To date, we identified Ets family transcription factors as a positive regulator of Prox1 function, and platelet-derived growth factor (PDGF) signal as a Prox1-regulated signal transduction pathway. In addition to them, we report, as a negative regulator of Prox1 expression, transforming growth factor-β (TGF-β), which is an inducer of endothelial mesenchymal transition (EndMT) in lymphatic endothelial cells, and its underlying molecular mechanism.

Journal

• The Journal of Japanese College of Angiology

  The Journal of Japanese College of Angiology 60 (11), 193-196, 2020-11-10

  Japanese College of Angiology

Keywords

• Prox1
• lymphatic endothelial cell
• platelet-derived growth factor
• Ets family transcription factor
• transforming growth factor-β

Details

• CRID: 1390286426515741952
• NII Article ID: 130007937886
• DOI: 10.7133/jca.20-00032
• ISSN: 18808840
• ISSN: 03871126
• Web Site: https://www.jstage.jst.go.jp/article/jca/60/11/60_20-00032/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021112838
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed