A Low Serum CCL4/MIP-1β Level May Predict a Severe Asthmatic Responsiveness to Mepolizumab
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- Suzukawa Maho
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan Clinical Research Center, National Hospital Organization Tokyo National Hospital, Japan
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- Ohshima Nobuharu
- Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan
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- Tashimo Hiroyuki
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan
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- Asari Isao
- Clinical Research Center, National Hospital Organization Tokyo National Hospital, Japan
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- Kobayashi Nobuyuki
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan
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- Shoji Shunsuke
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan
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- Tohma Shigeto
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan
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- Ohta Ken
- Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Japan Clinical Research Center, National Hospital Organization Tokyo National Hospital, Japan Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
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<p>Objective Mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, is effective for treating eosinophilic severe asthma. However, there is a need for more biomarkers that can predict the patient response to mepolizumab before starting therapy. This study aimed to identify a new biomarker in the serum that is able to accurately predict the responsiveness to mepolizumab. </p><p>Methods This study enrolled 11 patients who had all been diagnosed with severe eosinophilic asthma and were then administered mepolizumab every 4 weeks for at least 4 months. Blood samples were collected, and pulmonary function tests and questionnaires were administered at baseline and after 4, 8 and 16 weeks of treatment. The response to mepolizumab was then assessed based on the difference in the Asthma Quality of Life Questionnaire (AQLQ) score after 16 weeks of mepolizumab therapy compared with that at baseline. Patients with an increase in the AQLQ score of more than 0.5 were defined as responders. The cytokine levels in the blood were measured by LUMINEX 200 and ELISA. </p><p>Results There were 6 responders and 5 non-responders. The responders showed a significantly lower serum level of chemokine (C-C motif) ligand 4/macrophage inflammatory protein-1β (CCL4/MIP-1β) at baseline compared to the non-responders. Receiver operating characteristic curves to distinguish responders from non-responders using the baseline serum CCL4/MIP-1β level showed a good area under the curve of 0.9. The non-responders showed a significant increase in the level of CCL4/MIP-1β after 4 weeks compared to the baseline. </p><p>Conclusion A low baseline serum CCL4/MIP-1β level may be useful for predicting a good mepolizumab response in severe eosinophilic asthma. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 59 (22), 2849-2855, 2020-11-15
一般社団法人 日本内科学会