Pregnancy and Delivery in Patients With Repaired Congenital Heart Disease　― A Retrospective Japanese Multicenter Study ―

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  • Takatsuki Shinichi
    Department of Pediatrics, Toho University Omori Medical Center
  • Furutani Yoshiyuki
    Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University
  • Inai Kei
    Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University
  • Kobayashi Tohru
    Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development
  • Inuzuka Ryo
    Department of Pediatrics, The University of Tokyo Hospital
  • Uyeda Tomomi
    Department of Pediatric Cardiology, Sakakibara Heart Institute
  • Kamisago Mitsuhiro
    Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital
  • Muneuchi Jun
    Department of Pediatric Cardiology, Japan Health Care Community Organization Kyushu Hospital
  • Kaneko Masahide
    Department of Pediatric Cardiology, National Center for Child Health and Development
  • Misaki Yasushi
    Department of Pediatric Cardiology, National Center for Child Health and Development
  • Ono Hiroshi
    Department of Pediatric Cardiology, National Center for Child Health and Development
  • Kato Hitoshi
    Department of Pediatric Cardiology, National Center for Child Health and Development
  • Shimada Eriko
    Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University
  • Shinohara Tokuko
    Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University
  • Waki Kenji
    Department of Pediatrics, Kurashiki Central Hospital
  • Suda Kenji
    Department of Pediatrics, Kurume University Hospital
  • Hayabuchi Yasunobu
    Department of Pediatrics, Tokushima University Hospital
  • Ohki Hirotaka
    Department of Cardiology, Tokyo Metropolitan Children’s Medical Center
  • Ishizaki Reina
    Department of Pediatrics, Keio University School of Medicine
  • Maeda Jun
    Department of Cardiology, Tokyo Metropolitan Children’s Medical Center Department of Pediatrics, Keio University School of Medicine
  • Yamagishi Hiroyuki
    Department of Pediatrics, Keio University School of Medicine

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Abstract

<p>Background:Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.</p><p>Methods and Results:In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal.</p><p>Conclusions:Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.</p>

Journal

  • Circulation Journal

    Circulation Journal 84 (12), 2270-2274, 2020-11-25

    The Japanese Circulation Society

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