多糖類のフェノール誘導体を基盤とした組織構築を目指したバイオプリンティング技術の開発

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  • Development of bioprinting system for tissue regeneration based on phenol derivatives of polysaccharides

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<p>In this study, we developed a polysaccharide hydrogel for 3D bioprinting. 3D bioprinting is printing hydrogel containing cells or biocompatible materials by using 3D printer and it can be applied to tissue regeneration. It is important to develop a new hydrogel for bioprinting. Polysaccharide based hydrogel has high biocompatibility and it may have a great potential for tissue regeneration in bioprinting. Chitosan, that is one kind of polysaccharide, was reported as wound healing and cellular adhesive material. We chemically modified chitosan and achieved visible light gelation of chitosan. Visible light is not harmful gelation way for cells compared to ultraviolet gelation. Indeed, we showed that this bioink has good printability and thus it may have a great potential for bioprinting.</p>

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