Factorial Analysis of <i>Clostridioides Difficile</i> Colitis and Pseudomembranous Colitis Using JADER

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Author(s)

    • Takaya Risako
    • Division of Pharmacodynamics, Keio University Faculty of Pharmacy
    • Misawa Kana
    • Division of Pharmacodynamics, Keio University Faculty of Pharmacy
    • Tashiro Sho
    • Division of Pharmacodynamics, Keio University Faculty of Pharmacy
    • Enoki Yuki
    • Division of Pharmacodynamics, Keio University Faculty of Pharmacy

Abstract

<p><i>Clostridioides difficile</i> (<i>C</i>. <i>difficile</i>) colitis and pseudomembranous colitis are known as healthcare-associated intestinal infections. In this study, the incidence of <i>C. difficile</i> colitis and pseudomembranous colitis was investigated using the Japanese Adverse Drug Event Report (JADER). Using JADER data between April 2004 and September 2017, the patient who developed <i>C. difficile</i> colitis and pseudomembranous colitis were investigated. During the study period, 375 cases of <i>C. difficile</i> colitis and 903 cases of pseudomembranous colitis were reported. The numbers of reported cases of both <i>C. difficile</i> colitis and pseudomembranous colitis were largest in those in their 70s, accounting for 24.7% and 25.6%, respectively. Patients in their 60s-90s comprised the majority of all patients with both <i>C. difficile</i> colitis and pseudomembranous colitis. Both <i>C. difficile</i> colitis and pseudomembranous colitis were caused by antibiotics in many patients, and signals of all antibiotics were detected. In <i>C. difficile</i> colitis, signals of immunosuppressants, corticosteroids, and alkylating drugs were also detected among drugs other than antibiotics. For pseudomembranous colitis, the use of molecularly targeted drugs, antimetabolic drugs, and corticosteroids was reported other than antibiotics. Using JADER, we revealed risk factors for the development of <i>C. difficile</i> colitis and pseudomembranous colitis, and firstly revealed that molecularly targeted drugs other than antibiotics could also be potential risk factors. Our findings may be useful for the early detection of drug-induced <i>C. difficile</i> colitis and pseudomembranous colitis.</p>

Journal

  • BPB Reports

    BPB Reports 3(1), 1-6, 2020

    The Pharmaceutical Society of Japan

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