Differential Contractile Reactivity to Nucleotides in Femoral Arteries of OLETF and LETO Rats

• Matsumoto Takayuki

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Takayanagi Keisuke

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Kojima Mihoka

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Taguchi Kumiko

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Kobayashi Tsuneo

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

抄録

Extracellular nucleotides play an important role in the regulation of vascular function, and an abnormal vascular function is an important participant in the development and progression of diabetic vascular complications. The purpose of this study was to determine whether contractile responses induced by extracellular nucleotides and a dinucleotide, uridine adenosine tetraphosphate (Up₄A), in femoral arteries would be altered at the chronic stage of type 2 diabetes. We determined the changes in contractile reactivity induced by ATP, uridine triphosphate (UTP), uridine diphosphate (UDP), and Up₄A in the femoral arteries of Otsuka Long–Evans Tokushima Fatty (OLETF) rats (aged male type 2 diabetic rats) and, Long–Evans Tokushima Otsuka (LETO) rats (controls for OLETF rats). ATP-induced contractions were greater in OLETF rats than in LETO rats. UTP-induced contractions were lower in OLETF rats than in LETO rats. UDP- and Up₄A-induced contractions were similar between OLETF and LETO rats. The femoral artery contractile changes induced by the extracellular nucleotides and dinucleotide were similar when nitric oxide synthase was inhibited. These results suggest that the extent of femoral artery contractile reactivity to nucleotides/dinucleotides differs during long-term duration of type 2 diabetes.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 43 (12), 1987-1992, 2020-12-01

  公益社団法人 日本薬学会

キーワード

• contraction
• diabetes
• femoral artery
• nucleotide
• uridine adenosine tetraphosphate

詳細情報

• CRID: 1390567901491534976
• NII論文ID: 130007948697
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b20-00653
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 030782366
• PubMed: 33268721
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030782366
• Web Site: https://www.jstage.jst.go.jp/article/bpb/43/12/43_b20-00653/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021296563
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可