Retention Period of Amyloid β₁₋₄₂ in the Brain Extracellular Fluid as the Toxicological Determinant in Freely Moving Rats
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- Tamano Haruna
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Togo Junichi
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Sato Yuichi
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Shioya Aoi
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Tempaku Munekazu
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
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- Takeda Atsushi
- Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka
書誌事項
- タイトル別名
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- Retention Period of Amyloid β<sub>1–42</sub> in the Brain Extracellular Fluid as the Toxicological Determinant in Freely Moving Rats
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<p>The pathological significance of amyloid-β1–42 (Aβ1–42) dynamics is poorly understood in the brain extracellular compartment. Here we test which of the concentration or the retention is critical for Aβ1–42 toxicity after injection of equal dose into dentate granule cell layer of freely moving rats. The toxicity of Aβ1–42 (25 µM) was compared between injections at the rate of 0.25 µL/min for 4 min (fast injection) and 0.025 µL/min for 40 min (slow injection). Dentate gyrus long-term potentiation (LTP) was affected 1 and 2 h after the fast injection, but not 4 h. In contrast, LTP was affected even 72 h after the slow injection. Aβ1–42 staining 5 min after finish of the slow injection was more intense in the dentate granule cell layer than of the fast injection. The present study indicates that the retention of Aβ1–42 in the extracellular fluid is correlated with neuronal Aβ1–42 uptake and plays a key role in Aβ1–42 neurotoxicity. In the extracellular fluid of the dentate gyrus, the retention period of Aβ1–42 is much more critical for Aβ1–42 toxicity than Aβ1–42 concentration. It is likely that Aβ1–42 toxicity is accelerated by the disturbance of Aβ1–42 metabolism in the dentate gyrus.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 43 (12), 1975-1978, 2020-12-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1391412326421680896
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- NII論文ID
- 130007948719
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 030782350
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- PubMed
- 33268719
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可