Synthesis of CF<sub>3</sub>-Containing Isoindolinone Derivatives through Rhodium-catalyzed Oxidative Coupling of Benzamides with 2-Trifluoromethylacrylate

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Author(s)

    • Yoshimoto Risa
    • Department of Chemistry, Graduate School of Science, Osaka City University
    • Morisaka Hideaki
    • Department of Chemistry, Graduate School of Science, Osaka City University
    • Shibata Yu
    • Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology
    • Tanaka Ken
    • Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology
    • Satoh Tetsuya
    • Department of Chemistry, Graduate School of Science, Osaka City University

Abstract

<p>The oxidative coupling of benzamides with methyl 2-trifluoromethylacrylate proceeds smoothly under rhodium(III) catalysis to produce trifluoromethyl-substituted isoindolinone derivatives. The catalyst system [Cp<sup>E</sup>RhCl<sub>2</sub>]<sub>2</sub>/AgSbF<sub>6</sub> is effective for the oxidative coupling, while [Cp*RhCl<sub>2</sub>]<sub>2</sub>/AgSbF<sub>6</sub> leads to their redox-neutral coupling predominantly. The oxidative coupling reactions with related acrylates have also been examined.</p>

Journal

  • Chemistry Letters

    Chemistry Letters 49(12), 1481-1483, 2020

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130007956021
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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