Photo Responsive Drug Delivery System (DDS) Using Mesoporous Silica

• FUJIWARA Masahiro

  National Institute of Advanced Industrial Science and Technology (RICPT

Bibliographic Information

Other Title

• メソポーラスシリカを用いた光応答性ドラッグデリバリー
• メソポーラスシリカ オ モチイタ ヒカリ オウトウセイ ドラッグデリバリー

Abstract

Targeted drug delivery system (DDS) triggered by photo irradiation is described in this paper. A mesoporous silica with a coumarin substituent grafted to the outlet region can store a drug molecule in its mesopore, when the coumarin is dimerized by the irradiation of longer wavelength UV light to close the gate of the mesopore. The drug molecule carried to target part can be released from the mesopore by the cleavage of the coumarin dimer triggered by the irradiation of shorter wavelength UV light. The continuous photo isomerization of azobenzene induced by the simultaneous irradiation of UV and visible light promotes the release of a drug molecule from the mesopore. Double modified mesoporous silica with the coumarin and the azobenzene substituents realizes an advanced targeted drug delivery. Using this silica, both the release and the release rate of drug molecule in the mesopore can be controlled by photo irradiations.

Journal

• The Review of Laser Engineering

  The Review of Laser Engineering 45 (11), 691-, 2017

  The Laser Society of Japan

Keywords

• Targeted drug delivery
• Mesoporous silica
• Photo chromism
• Coumarin
• Azobenzene

Details

• CRID: 1391694356244049920
• NII Article ID: 130007957343
• NII Book ID: AN00255326
• DOI: 10.2184/lsj.45.11_691
• ISSN: 13496603
• ISSN: 03870200
• NDL BIB ID: 028706045
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028706045
• Web Site: https://www.jstage.jst.go.jp/article/lsj/45/11/45_691/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed