Comparison between quantitative and subjective assessments of chemotherapy-induced peripheral neuropathy in cancer patients: A prospective cohort study

DOI HANDLE Web Site 27 References Open Access
  • SAITO Takashi
    Department of Public Health Sciences, Kobe University Graduate School of Health Sciences
  • MAKIURA Daisuke
    Division of Rehabilitation, Kobe University Hospital
  • INOUE Junichiro
    Division of Rehabilitation, Kobe University Hospital
  • DOI Hisayo
    Division of Nursing, Kobe University Hospital
  • YAKUSHIJIN Kimikazu
    Department of Medical Oncology and Hematology, Kobe University Hospital
  • OKAMURA Atsuo
    Department of Medical Oncology and Hematology, Kakogawa Central City Hospital
  • MATSUOKA Hiroshi
    Department of Medical Oncology and Hematology, Kobe University Hospital
  • MUKOHARA Toru
    Department of Breast and Medical Oncology, National Cancer Center Hospital East
  • SAURA Ryuichi
    Department of Physical and Rehabilitation Medicine, Osaka Medical College
  • SAKAI Yoshitada
    Department of Rehabilitation Medicine, Kobe University Graduate School of Medicine
  • ONO Rei
    Department of Public Health Sciences, Kobe University Graduate School of Health Sciences

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Abstract

<p>Objective: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event experienced by cancer patients. In general, CIPN is evaluated subjectively based on patient self-assessment or clinician-reported scales; evidence supporting the utility and validity of quantitative sensory tests (QST) is lacking in this patient population. The aim of this study was to objectively assess CIPN of lower extremities by QSTs, and to evaluate the concordance between QSTs and subjective assessments. Methods: In this prospective cohort study, outpatients with cancer receiving chemotherapy were recruited at a single university hospital. We assessed CIPN at the lower extremities at baseline and three months after baseline. The QSTs were performed by applying a monofilament and a tuning fork to determine touch and vibration thresholds, respectively, at the affected site. Subjective assessments were performed based on the visual analog scale (VAS) and the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) toxicity grade. Kappa coefficients were calculated to evaluate the concordance between QSTs and subjective assessments. Results: After exclusion and drop-outs during follow-up, nineteen patients were included in the analysis. The prevalence of patients with abnormal sensation was 37% based on QSTs, 32% based on the VAS, and 14% based on CTCAE grading, respectively. Kappa coefficients were 0.32 between QSTs and VAS, and 0.28 between QSTs and CTCAE. Conclusions: The concordance rates between quantitative and subjective assessments were low. CIPN should be assessed using both quantitative and subjective assessments.</p>

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