Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19
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- Takahashi Yuwa
- Department of Complete Denture Prosthodontics, Nihon University School of Dentistry Department of Microbiology, Nihon University School of Dentistry
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- Watanabe Norihisa
- Department of Microbiology, Nihon University School of Dentistry
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- Kamio Noriaki
- Department of Microbiology, Nihon University School of Dentistry
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- Kobayashi Ryutaro
- Oral and Maxillofacial Surgery, The Nippon Dental University Hospital
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- Iinuma Toshimitsu
- Department of Complete Denture Prosthodontics, Nihon University School of Dentistry
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- Imai Kenichi
- Department of Microbiology, Nihon University School of Dentistry
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<p>Coronavirus infectious disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a pandemic in March 2020 by the World Health Organization. Periodontitis, one of the most prevalent diseases worldwide, leads to alveolar bone destruction and subsequent tooth loss, and develops due to pro-inflammatory cytokine production induced by periodontopathic bacteria. Periodontopathic bacteria are involved in respiratory diseases, including aspiration pneumonia and chronic obstructive pulmonary disease (COPD), and other systemic diseases, such as diabetes and cardiovascular disease. Patients with these diseases have an increased COVID-19 aggravation rate and mortality. Because aspiration of periodontopathic bacteria induces the expression of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, and production of inflammatory cytokines in the lower respiratory tract, poor oral hygiene can lead to COVID-19 aggravation. Conversely, oral care, including periodontal treatment, prevents the onset of pneumonia and influenza and the exacerbation of COPD. The reduced chance of receiving professional oral care owing to long-term hospitalization of patients with COVID-19 may increase the aggravation risk of infection in the lower respiratory tract. It can be hypothesized that periodontopathic bacteria are involved in the COVID-19 aggravation and therefore, the management of good oral hygiene potentially contributes to its prevention.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ
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Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ 63 (1), 1-3, 2021
日本大学歯学部