The impact of aerobic fitness on arterial stiffness and adrenal cortex hormones in middle-aged and older adults

• Akazawa Nobuhiko

  Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan Japan Institute of Sports Sciences, Tokyo 115-0056, Japan

• Tanahashi Koichiro

  Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan Department of Health and Sports Sciences, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan

• Kosaki Keisei

  Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan Japan Society for the Promotion of Science, Tokyo 102-0083, Japan Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan

• Kumagai Hiroshi

  Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan Japan Society for the Promotion of Science, Tokyo 102-0083, Japan Graduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, Japan

• Oikawa Satoshi

  Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8574, Japan

• Hamasaki Ai

  Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8574, Japan

• Maeda Seiji

  Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki 305-8574, Japan

Abstract

An increase in arterial stiffness with advance aging is a risk for cardiovascular disease. Cardiovascular dysfunction is associated with the imbalance of adrenal cortex hormones, especially with the cortisol/dehydroepiandrosterone sulfate (DHEAs) ratio. However, the impact of aerobic fitness on arterial stiffness and cortisol/DHEAs ratio is unclear. The aim of this study was to investigate the relationship between aerobic fitness, arterial stiffness, and cortisol/DHEAs ratio. A total of 198 middle-aged and older adults (aged 50–79 years old) participated in this study. The aerobic fitness evaluated by peak oxygen consumption (VO_2peak), carotid-femoral pulse wave velocity (cfPWV) as an indicator of arterial stiffness, and serum cortisol and DHEAs and their ratio were measured. The subjects were divided into the lower (n = 100) and the higher (n = 98) aerobic fitness groups based on the median value of VO_2peak. There were no significant differences in serum cortisol and DHEAs concentration alone between the lower and higher fitness groups. However, the cortisol/DEHAs ratio and cfPWV in the higher fitness group was smaller than in the lower fitness group (p < 0.05). The cortisol/DHEAs ratio was significantly correlated with cfPWV (r = 0.159, p < 0.05). These findings suggest that the cortisol/DHEAs ratio is associated with aerobic fitness and arterial stiffness in middle-aged and older adults.

Journal

• Endocrine Journal

  Endocrine Journal 67 (12), 1199-1205, 2020

  The Japan Endocrine Society

Keywords

• Aerobic capacity
• Arterial stiffness
• Steroid
• Aging

Details

• CRID: 1390849931317006720
• NII Article ID: 130007962225
• DOI: 10.1507/endocrj.ej20-0211
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 32741887
• Web Site: https://www.jstage.jst.go.jp/article/endocrj/67/12/67_EJ20-0211/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021283352
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed