SLC37A2, a phosphorus-related molecule, increases in smooth muscle cells in the calcified aorta
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- Tani Mariko
- Graduate School of Human Science and Environment, University of Hyogo
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- Tanaka Sarasa
- Graduate School of Human Science and Environment, University of Hyogo
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- Oeda Chihiro
- School of Human Science and Environment, University of Hyogo
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- Azumi Yuichi
- Graduate School of Human Science and Environment, University of Hyogo
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- Kawamura Hiromi
- Graduate School of Human Science and Environment, University of Hyogo
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- Sakaue Motoyoshi
- Graduate School of Human Science and Environment, University of Hyogo
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- Ito Mikiko
- Graduate School of Human Science and Environment, University of Hyogo
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Abstract
<p>Vascular calcification is major source of cardiovascular disease in patients with chronic kidney disease. Hyperphosphatemia leads to increased intracellular phosphorus influx, which leads to an increase in osteoblast-like cells in vascular smooth muscle cell. PiT-1 transports phosphate in vascular smooth muscle cell. However, the mechanism of vascular calcification is not completely understood. This study investigated candidate phosphorus-related molecules other than PiT-1. We hypothesized that phosphorus-related molecules belonging to the solute-carrier (SLC) superfamily would be involved in vascular calcification. As a result of DNA microarray analysis, we focused on SLC37A2 and showed that mRNA expression of these cells increased on calcified aotic smooth muscle cells (AoSMC). SLC37A2 has been reported to transport both glucose-6-phosphate/phosphate and phosphate/phosphate exchanges. In vitro analysis showed that SLC37A2 expression was not affected by inflammation on AoSMC. The expression of SLC37A2 mRNA and protein increased in calcified AoSMC. In vivo analysis showed that SLC37A2 mRNA expression in the aorta of chronic kidney disease rats was correlated with osteogenic marker genes. Furthermore, SLC37A2 was expressed at the vascular calcification area in chronic kidney disease rats. As a result, we showed that SLC37A2 is one of the molecules that increase with vascular calcification in vitro and in vivo.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 68 (1), 23-31, 2021
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Details 詳細情報について
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- CRID
- 1391975831225352576
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- NII Article ID
- 130007965281
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed