Endosonographic features in patients with non-alcoholic early chronic pancreatitis improved with treatment at one year follow up
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- Higuchi Kazutoshi
- Department of Gastroenterology, Nippon Medical School
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- Futagami Seiji
- Department of Gastroenterology, Nippon Medical School
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- Yamawaki Hiroshi
- Department of Gastroenterology, Nippon Medical School
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- Murakami Makoto
- Department of Gastroenterology, Nippon Medical School
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- Kirita Kumiko
- Department of Gastroenterology, Nippon Medical School
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- Agawa Shuhei
- Department of Gastroenterology, Nippon Medical School
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- Ikeda Go
- Department of Gastroenterology, Nippon Medical School
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- Noda Hiroto
- Department of Gastroenterology, Nippon Medical School
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- Kodaka Yasuhiro
- Department of Gastroenterology, Nippon Medical School
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- Ueki Nobue
- Department of Gastroenterology, Nippon Medical School
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- Kaneko Keiko
- Department of Gastroenterology, Nippon Medical School
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- Gudis Katya
- Department of Gastroenterology, Nippon Medical School
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- Ohashi Ryuji
- Department of Diagnostic Pathology, Nippon Medical School Musashi Kosugi Hospital
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- Iwakiri Katsuhiko
- Department of Gastroenterology, Nippon Medical School
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<p>Since the prevention of early chronic pancreatitis (ECP) into chronic pancreatitis might be critical for the reduction of pancreatic cancer, we tried to clarify the pathophysiology of ECP patients, focusing on ECP patients without alcoholic chronic pancreatitis. 27 ECP patients without alcoholic chronic pancreatitis and 33 patients with functional dyspepsia with pancreatic enzyme abnormalities (FD-P) were enrolled in this study. Diagnosis of ECP was made when imaging findings showed the presence of more than 2 out of 7 endoscopic ultrasound features. Duodenal degranulated eosinophils and glucagon-like peptide 1 producing cells were estimated by immunostaining. There were no significant differences in characteristics and psychogenic factors between ECP and FD-P patients. Interestingly, endoscopic ultrasound score in ECP patients significantly improved, albeit clinical symptoms in ECP patients showed no improvement at one year follow up. The extent of migration of duodenal degranulated eosinophils in FD-P patients was significantly higher compared to that in ECP patients. The levels of elastase-1 and trypsin in ECP patients with improved endoscopic ultrasound features were significantly reduced by the treatment. Further studies will be needed to clarify whether clinical symptoms and endoscopic ultrasound features in ECP patients without alcoholic chronic pancreatitis were improved in longer follow up study.</p>
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 68 (1), 86-94, 2021
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1391131406295224448
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- NII論文ID
- 130007965287
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可