Anti-MuSK Positive Myasthenia Gravis with Anti-Lrp4 and Anti-titin Antibodies
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- Yamashita Rika
- Department of Neurology, Osaka University Hospital, Japan
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- Shimizu Mikito
- Department of Neurology, Osaka University Hospital, Japan
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- Baba Kousuke
- Department of Neurology, Osaka University Hospital, Japan
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- Beck Goichi
- Department of Neurology, Osaka University Hospital, Japan
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- Kinoshita Makoto
- Department of Neurology, Osaka University Hospital, Japan
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- Okuno Tatsusada
- Department of Neurology, Osaka University Hospital, Japan
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- Higuchi Osamu
- Department of Clinical Research, Nagasaki Kawatana Medical Center, Japan
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- Mochizuki Hideki
- Department of Neurology, Osaka University Hospital, Japan
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Abstract
<p>In addition to muscle nicotinic acetylcholine receptor (AChR) and muscle-specific kinase (MuSK), low-density lipoprotein receptor (Lrp4) has recently been discovered to be a novel target antigen among patients with seronegative myasthenia gravis (MG). We herein report the findings of a 62-year-old patient who showed positivity for anti-MuSK, anti-Lrp4, and anti-titin antibodies. The patient developed MG crisis following a 10-year history of intermittent double vision with ptosis, and a 7-year history of dropped head. Our detailed clinical, laboratory, and therapeutic descriptions highlight its unique characteristics of anti-MuSK-antibody positive MG accompanied by anti-Lrp4 and anti-titin antibodies. </p>
Journal
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- Internal Medicine
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Internal Medicine 60 (1), 137-140, 2021-01-01
The Japanese Society of Internal Medicine