Fabrication and evaluation of ascorbic acid phosphate-loaded spherical porous hydroxyapatite/octacalcium phosphate granules
-
- KAMITAKAHARA Masanobu
- Graduate School of Environmental Studies, Tohoku University
-
- ISHII Airi
- Graduate School of Environmental Studies, Tohoku University
-
- MATSUBARA Hideaki
- Graduate School of Environmental Studies, Tohoku University
-
- KAWASHITA Masakazu
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
-
- FURUYA Maiko
- Graduate School of Dentistry, Tohoku University
-
- KANETAKA Hiroyasu
- Graduate School of Dentistry, Tohoku University
Abstract
<p>The spherical porous granules of octacalcium phosphate (OCP) and hydroxyapatite (HA) have the potential for applications in scaffolds for bone regeneration. The spherical porous alpha-tricalcium phosphate granules were immersed in a pH 5.0 buffer solution that contained 0.1 mM of ascorbic acid phosphate (AscP), an osteogenesis-promoting drug, at 60 °C. This resulted in the fabrication of the AscP-loaded spherical porous HA/OCP granules. The OCP and HA phases were concentrated at the surface and interior of the granules, respectively. Furthermore, the HA/OCP core/shell-like structure of the granules was observed for the first time. The loaded AscP in the HA/OCP granules was slowly released in a pH 7.4 buffer solution. The differentiation of the osteoblast-like cells was promoted by the AscP-loaded HA/OCP granules. These granules possessed the potential for applications in artificial bones to promote bone regeneration.</p>
Journal
-
- Journal of the Ceramic Society of Japan
-
Journal of the Ceramic Society of Japan 129 (1), 60-65, 2021-01-01
The Ceramic Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1391131406295346688
-
- NII Article ID
- 130007965538
-
- ISSN
- 13486535
- 18820743
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed
