書誌事項
- タイトル別名
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- Development of Pd-Catalyzed Denitrative Couplings
抄録
<p>Transition metal-catalyzed cross-coupling between aryl halides and nucleophiles is one of the most reliable C-C and C-heteroatom bond forming reactions. However, preparation of haloarenes usually requires multi-step operation, making the whole cross-coupling process inefficient. Nitroarenes, synthesized by a single-step nitration of arenes, can be attractive alternatives as electrophiles in cross-coupling methodology, but inherent inertness of C(sp2)-NO2 bonds toward metal catalysts has been a bottleneck of general denitrative transformations. Recently, we have overcome this obstacle and achieved direct activation of Ar-NO2 bonds by using Pd/BrettPhos catalysis. Herein, we describe the development of denitrative couplings by Pd/BrettPhos catalyst and its unique suitability from a mechanistic point of view. Deep understanding of reaction mechanism also enabled us to design more active Pd/NHC system.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 79 (1), 11-21, 2021-01-01
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1391131406304615040
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- NII論文ID
- 130007966738
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- ISSN
- 18836526
- 00379980
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可