Thymus and activation-regulated chemokine (TARC/CCL17) predicts decline of pulmonary function in patients with chronic obstructive pulmonary disease

• Machida Hiroyoshi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Inoue Sumito

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Shibata Yoko

  Department of Pulmonary Medicine, Fukushima Medical University

• Kimura Tomomi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Sato Kento

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Abe Koya

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Murano Hiroaki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Yang Sujeong

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Nakano Hiroshi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Sato Masamichi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Nemoto Takako

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Sato Chisa

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Nishiwaki Michiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Yamauchi Keiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Igarashi Akira

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Tokairin Yoshikane

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

• Watanabe Masafumi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

Abstract

Background: The deterioration of pulmonary function, such as FEV₁-decline, is strongly associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, few investigations shed light on useful biomarkers for predicting the decline of pulmonary function. We evaluated whether thymus and activation-regulated chemokine (TARC), a Th2 inflammation marker, could predict rapid FEV₁-decline in COPD patients. Methods: We recruited 161 patients with stable COPD and performed pulmonary function test once every six months. At the time of registration, blood tests, including serum levels of TARC were performed. We assessed the correlation between changes in parameters of pulmonary function tests and serum levels of TARC. The rapid-decline in pulmonary function was determined using 25th percentile of change in FEV₁ or FEV₁ percent predicted (%FEV₁) per year. Results: In the FEV₁-rapid-decline group, the frequency of exacerbations, the degree of emphysema, and serum levels of TARC was higher than in the non-rapid-decline group. When using %FEV₁ as a classifier instead of FEV₁, age, the frequency of exacerbations, the degree of emphysema and serum levels of TARC in the rapid-decline group was significantly greater than those in the non-rapid-decline group. In univariate logistic regression analysis, TARC was the significant predictive factor for rapid-decline group. In multivariate analysis adjusted for emphysema, serum levels of TARC are independently significant predicting factors for the rapid-decline group. Conclusions: TARC is an independent predictive biomarker for the rapid-decline in FEV₁. Measuring serum TARC levels may help the management of COPD patients by predicting the risk of FEV₁ decline.

Journal

• Allergology International

  Allergology International 70 (1), 81-88, 2021

  Japanese Society of Allergology

Keywords

• Biomarker
• Chronic obstructive pulmonary disease (COPD)
• Forxed expiratory volume in one second (FEV₁)
• Pulmonary function
• Thymus and activation-regulated chemokine (TARC/CCL17)

Details

• CRID: 1391694356258046848
• NII Article ID: 130007966761
• DOI: 10.1016/j.alit.2020.04.004
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S132389302030054X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S132389302030054X?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2021283429
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed