The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions

• Kanda Akira

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University Allergy Center, Kansai Medical University Department of Pathology and Laboratory Medicine, Kansai Medical University

• Yun Yasutaka

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Bui Dan Van

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Nguyen Linh Manh

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Kobayashi Yoshiki

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University Allergy Center, Kansai Medical University

• Suzuki Kensuke

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Mitani Akitoshi

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Sawada Shunsuke

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Hamada Satoko

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

• Asako Mikiya

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University Allergy Center, Kansai Medical University

• Iwai Hiroshi

  Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University

抄録

Eosinophils not only play a critical role in the pathogenesis of eosinophil-associated diseases, but they also have multiple important biological functions, including the maintenance of homeostasis, host defense against infections, immune regulation through canonical Th1/Th2 balance modulation, and anti-inflammatory and anti-tumorigenic activities. Recent studies have elucidated some emerging roles of eosinophils in steady-state conditions; for example, eosinophils contribute to adipose tissue metabolism and metabolic health through alternatively activated macrophages and the maintenance of plasma cells in intestinal tissue and bone marrow. Moreover, eosinophils exert tissue damage through eosinophil-derived cytotoxic mediators that are involved in eosinophilic airway inflammation, leading to diseases including asthma and chronic rhinosinusitis with nasal polyps characterized by fibrin deposition through excessive response by eosinophils-induced. Thus, eosinophils possessing these various effects reflect the heterogenous features of these cells, which suggests the existence of distinct different subpopulations of eosinophils between steady-state and pathological conditions. Indeed, a recent study demonstrated that instead of dividing eosinophils by classical morphological changes into normodense and hypodense eosinophils, murine eosinophils from lung tissue can be phenotypically divided into two distinct subtypes: resident eosinophils and inducible eosinophils gated by Siglec-F^int CD62L⁺ CD101^low and Siglec-F^high CD62L^– CD101^high, respectively. However, it is difficult to explain every function of eosinophils by rEos and iEos, and the relationship between the functions and subpopulations of eosinophils remains controversial. Here, we overview the multiple roles of eosinophils in the tissue and their biological behavior in steady-state and pathological conditions. We also discuss eosinophil subpopulations.

収録刊行物

• Allergology International

  Allergology International 70 (1), 9-18, 2021

  一般社団法人日本アレルギー学会

キーワード

• Asthma
• Homeostasis
• Hypodense eosinophils
• Inducible eosinophils
• Resident eosinophils

詳細情報

• CRID: 1390849931327942400
• NII論文ID: 130007966816
• DOI: 10.1016/j.alit.2020.11.001
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893020301441?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893020301441?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2021283420
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可