Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system
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- SARKAR Sonjoy
- Laboratory of Veterinary Anatomy, The United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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- HOMMA Takeshi
- Laboratory of Veterinary Anatomy, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan
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- ONOUCHI Sawa
- Laboratory of Veterinary Anatomy, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan
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- SHIMIZU Yasutake
- Laboratory of Veterinary Physiology, The Joint Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
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- SHIINA Takahiko
- Laboratory of Veterinary Physiology, The Joint Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
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- NABEKA Hiroaki
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan
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- MATSUDA Seiji
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan
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- SAITO Shouichiro
- Laboratory of Veterinary Anatomy, The United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan Laboratory of Veterinary Anatomy, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan Laboratory of Veterinary Anatomy, The Joint Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
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Abstract
<p>G protein-coupled receptor (GPR) 37 and GPR37L1 are known to modulate the dopaminergic neuron activity, and recently, they are identified as candidate prosaposin receptors. Intercellular prosaposin is proteolytically processed into four saposins, each of which acts as a sphingolipid hydrolase activator in the lysosome. In contrast, extracellular prosaposin exerts a trophic effect on neurons via GPR37 and GPR37L1. In this study, the expression patterns of GPR37 and GPR37L1 in the mouse digestive system were examined immunohistochemically. The islets of Langerhans of the pancreas showed intense immunoreactivity for GPR37 and GPR37L1. Weak immunoreactivity for GPR37 and GPR37L1 was found in the nerve plexuses of the esophagus and small and large intestines. Colocalization of GPR37 and tyrosine hydroxylase immunoreactivity was observed in the neuron of the nerve plexus of the large intestine. This study suggests the possibility that prosaposin affects the function of islet-secreting cells. Also, the expression of GPR37 and GPR37L1 in the nerve plexus suggests that prosaposin exerts a trophic effect not only in the central nervous system, but also in the enteric nervous system.</p>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 83 (1), 1-8, 2021
JAPANESE SOCIETY OF VETERINARY SCIENCE