Absorption Kinetics of Ethanolamine Plasmalogen and Its Hydrolysate in Mice

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  • Yamashita Shinji
    Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Fujiwara Kazufumi
    Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Tominaga Yuki
    Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Nguma Ephantus
    Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Takahashi Takumi
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
  • Otoki Yurika
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
  • Yamamoto Ayaka
    Yaizu Suisankagaku Industry Co., Ltd.
  • Higuchi Ohki
    Food and Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University
  • Nakagawa Kiyotaka
    Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
  • Kinoshita Mikio
    Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Miyazawa Teruo
    Food and Biotechnology Platform Promoting Project, New Industry Creation Hatchery Center (NICHe), Tohoku University

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Abstract

<p>Ethanolamine plasmalogen (PlsEtn), a subclass of ethanolamine glycerophospholipid (EtnGpl), has been reported to have many biological and dietary functions. In terms of PlsEtn absorption, some studies have reported that PlsEtn is re-esterized at the sn-2 position using lymph cannulation and the everted jejunal sac model. In this study, we aimed to better understand the uptake kinetics of PlsEtn and increase its absorption. We thus compared the uptake kinetics of PlsEtn with that of the lyso-form, in which the fatty acid at the sn-2 position was hydrolyzed enzymatically. Upon administration of EtnGpl (extracted from oysters or ascidians, 75.4 mol% and 88.4 mol% of PlsEtn ratio, respectively), the plasma PlsEtn species in mice showed the highest levels at 4 or 8 hours after administration. In the contrast, administration of the EtnGpl hydrolysate, which contained lysoEtnGpl and free fatty acids, markedly increased the plasma levels of PlsEtn species at 2 h after administration. The area under the plasma concentration-time curve (AUC), especially the AUC0-4 h of PlsEtn species, was higher with hydrolysate administration than that with EtnGpl administration. These results indicate that EtnGpl hydrolysis accelerated the absorption and metabolism of PlsEtn. Consequently, using a different experimental approach from that used in previous studies, we reconfirmed that PlsEtn species were absorbed via hydrolysis at the sn-2 position, suggesting that hydrolysis in advance could increase PlsEtn uptake.</p>

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