Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With <i>SLCO2A1</i> Gene, and Intestinal Behçet’s Disease in Japan in 2017: A Nationwide Survey
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- Oba Mari S.
- Department of Medical Statistics, Toho University
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- Murakami Yoshitaka
- Department of Medical Statistics, Toho University
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- Nishiwaki Yuji
- Department of Environmental and Occupational Health, Toho University
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- Asakura Keiko
- Department of Environmental and Occupational Health, Toho University
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- Ohfuji Satoko
- Department of Public Health, Osaka City University Graduate School of Medicine
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- Fukushima Wakaba
- Department of Public Health, Osaka City University Graduate School of Medicine
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- Nakamura Yosikazu
- Department of Public Health, Jichi Medical University
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- Suzuki Yasuo
- Department of Internal Medicine, Toho University Sakura Medical Center
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Abstract
<p>Background: Cronkhite-Canada syndrome (CCS), chronic enteropathy associated with SLCO2A1 gene (CEAS), and intestinal Behçet’s disease (BD) are classified as intractable intestinal disorders in Japan. However, the national prevalence of these diseases remains unknown. We performed a nationwide survey to estimate the patient numbers and prevalence rates of these diseases throughout Japan in 2017.</p><p>Methods: We conducted a mail-based survey targeting hospitals across Japan to estimate the annual numbers of patients with CCS, CEAS, and intestinal BD in 2017. Using a stratified random sampling method, we selected 2,979 hospital departments and asked them to report the number of patients who met specific diagnostic criteria. The total number of patients for each disease was estimated by multiplying the reported numbers by the reciprocal of the sampling rate and response rate. The corresponding prevalence rates per 1,000,000 population were calculated based on the mid-year population of Japan in 2017.</p><p>Results: The overall survey response rate was 68.1% (2,029 departments). The estimated numbers of patients with CCS, CEAS, and intestinal BD were 473 (95% confidence interval [CI], 357–589), 388 (95% CI, 289–486), and 3,139 (95% CI, 2,749–3,529), respectively; the prevalence rates per 1,000,000 population were 3.7 (male: 4.0; female: 3.5), 3.1 (male: 3.0; female: 3.1), and 24.8 (male: 24.5; female: 25.0), respectively. The male-to-female ratios were 1.10, 0.94, and 0.93 for patients with CCS, CEAS, and intestinal BD, respectively.</p><p>Conclusions: Estimates of the national prevalence of CCS, CEAS, and intestinal BD in Japan were generated and found to be higher than those previously reported.</p>
Journal
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- Journal of Epidemiology
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Journal of Epidemiology 31 (2), 139-144, 2021-02-05
Japan Epidemiological Association
