Development of new synthetic methods for collective synthesis of biologically active natural products

• Nishikawa Toshio

  Graduate School of Bioagricultural Sciences, Nagoya University

Bibliographic Information

Other Title

• 生物活性天然物の網羅的合成のための新合成方法論の開発

Abstract

Collective syntheses of two natural products on the basis of their biosynthetic proposals are described. Chaxines, steroidal natural products isolated from a mushroom, were synthesized from ergosterol in 7 steps by photo-induced electrocyclic reaction and Baeyer-Villiger reaction as key steps. Oscillatoxin D and its related compounds isolated from marine cyanobacteria were synthesized by cyclization of the spiroether structure from a common intermediate possessing the dihydropyrone structure. Biologocal evaluation of the compounds obtained by these two collective syntheses revealed the unique biological activities respectively.

Journal

• MEDCHEM NEWS

  MEDCHEM NEWS 29 (4), 193-197, 2019-11-01

  The Pharmaceutical Society of Japan

Keywords

• natural product synthesis
• collective synthesis
• biosynthetic hypothesis
• chaxine
• oscillatoxin

Details

• CRID: 1390850092197042816
• NII Article ID: 130007981798
• DOI: 10.14894/medchem.29.4_193
• ISSN: 24328626
• ISSN: 24328618
• Web Site: https://search.jamas.or.jp/link/ui/2021363980
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed