Cytological investigation of deep-layer squamous cells in oral cytology

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  • SUEMITSU Masaaki
    Department of Pathology, Nihon University School of Dentistry at Matsudo
  • MATSUMOTO Takashi
    Department of Diagnostic Pathology, Nihon University Hospital at Matsudo
  • SETO Hiroyuki
    Nihon University Graduate School of Dentistry at Matsudo, Oral Pathology
  • NAKAYAMA Mitsuko
    Department of Pathology, Nihon University School of Dentistry at Matsudo
  • MORIKAWA Miyuki
    Department of Pathology, Nihon University School of Dentistry at Matsudo
  • YOKOYAMA Megumi
    Department of Physiology, Nihon University School of Dentistry at Matsudo
  • YAMAMOTO Hiroshi
    Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
  • UTSUNOMIYA Tadahiko
    Department of Pathology, Nihon University School of Dentistry at Matsudo
  • UKIGAYA Masayuki
    Department of Diagnostic Pathology, Nihon University Hospital at Matsudo
  • KUYAMA Kayo
    Department of Pathology, Nihon University School of Dentistry at Matsudo

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  • 口腔細胞診における深層型扁平上皮細胞の細胞学的検討

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Abstract

<p>Objective : The aim of this study was to clarify the cytological characteristics of deep-layer squamous cells by cytological classification the cytologic diagnosis and to quantify of subjective diagnosis in screening. We performed analysis of the cytological images and consider the cytological characteristics by cytological classification the cytologic diagnosis.</p><p>Study Design : The subjects of this study were oral cytology specimens obtained from the lateral tongue of 384 subjects at Nihon University Hospital at Matsudo, between January and December 2016. The cytological images were analyzed using an image analysis software to quantitatively measure the cell area, nuclear area, N/C ratio, nuclear irregularity and hyperchromasia.</p><p>Results : Deep-layer squamous cells were seen in 27 cases [8.6% (27/314)] of negative for intraepithelial lesion or malignancy (NILM), 1 case [2.0% (1/50)] of squamous intraepithelial lesion or dysplasia, 8 cases [40.0% (8/20)] of squamous cell carcinoma (SCC). The average nuclear area was 66.0μm2 (34.8) in cases of NILM and 82.6μm2 (43.7) in cases of SCC. The average nuclear irregularity index was 1.25 (0.08) in cases of NILM and 1.29 (0.09) in cases of SCC. A significant difference was found in the nuclear area (p=0.042) and nuclear irregularity index between NILM and SCC (p=0.028).</p><p>Conclusion : The nuclear area and nuclear irregularity index of the deep-layer squamous cells were higher in cases of SCC as compared to cases of NILM. These findings are suggested as being potentially helpful in oral cytological diagnosis.</p>

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