Effects of Exogenous Biliverdin Treatment on Neurobehaviors in Mice

• Li Yueyi

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University

• Dong Yan

  Intensive Care Unit of Hebei Hospital of Traditional Chinese Medicine, Hebei University of Chinese Medicine

• Meng Li

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University

• Yu Panpan

  Department of State Assets and Laboratory Administrative, Hebei Medical University

• Zhao Penghui

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University

• Gong Miao

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University

• Gao Qiang

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University

• Shi Haishui

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University

• Meng Cuili

  Department of Biochemistry, School of Basic Medicine, Xingtai Medical College

• Gao Yuan

  Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University

抄録

The neuroprotective effects of heme oxygenase (HO) have been well investigated. The potential effects of exogenous supplementation of biliverdin (BVD), one of the main products catalyzed by HO, on neurobehaviors are still largely unknown. The present study aimed to investigate the effects of BVD treatment on depression, anxiety, and memory in adult mice. Mice were injected with BVD through tail vein daily for a total 5 d, and depression- and anxiety-like behaviors were conducted by using open field test (OFT), novelty suppressed feeding (NSF), forced swimming test (FST) and tail suspension test (TST) since the third day of BVD administration. Novel object recognition (NOR) paradigm was used for memory formation test. After the final test, serum and hippocampal levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) of mice were analyzed by enzyme-linked immunosorbent assay (ELISA). The results showed that BVD treatment at low dose (2 mg/kg) induced depression-like behaviors, and high dose (8 mg/kg) BVD injection increased anxiety-like behaviors and impaired memory formation in mice. ELISA data showed that BVD treatment significantly increased hippocampal IL-6 and TNF-α level while only decreasing serum IL-6 level of mice. The present data suggest that exogenous BVD treatment induced depression- and anxiety-like phenotypes, which may be related to inflammatory factors, providing BVD may be a potential target for the prevention of mental disorders.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 44 (3), 325-331, 2021-03-01

  公益社団法人 日本薬学会

キーワード

• biliverdin
• depression
• anxiety
• memory
• inflammation

詳細情報

• CRID: 1390850247500449408
• NII論文ID: 130007993407
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b20-00340
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 031309366
• PubMed: 33642542
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031309366
• Web Site: https://www.jstage.jst.go.jp/article/bpb/44/3/44_b20-00340/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022034607
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可