Regulation of redox signaling by reactive sulfur species
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- Kasamatsu Shingo
- Department of Biological Science, Graduate School of Science, Osaka Prefecture University
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- Ihara Hideshi
- Department of Biological Science, Graduate School of Science, Osaka Prefecture University
Abstract
<p>Reactive sulfur species, such as cysteine persulfide, are produced endogenously at significant levels in cells and have rapidly emerged as common biomolecules. By virtue of improved analytical methods for detecting reactive persulfides, it has been demonstrated that these reactive molecules exhibit unique chemical properties and are present in various forms in vivo. Accumulating evidence has suggested that persulfides may be involved in a variety of biological processes, such as antioxidant and anti-inflammatory responses, biosynthesis of sulfur-containing molecules, mitochondrial energy metabolism via sulfur respiration, and cytoprotection via regulation of redox signal transduction induced by endogenous and exogenous electrophiles. Elucidation of the persulfide-dependent metabolism of redox signals is expected to facilitate our understanding of the importance of persulfides in regulating redox signals.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 68 (2), 111-115, 2021-03-01
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Details 詳細情報について
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- CRID
- 1390287297545817856
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- NII Article ID
- 130007993427
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- ISSN
- 18805086
- 09120009
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed