Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium

DOI Web Site Web Site PubMed 1 Citations 9 References
  • Lee Jin-Yong
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Universityn
  • Mori Chikage
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Universityn
  • Tokumoto Maki
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Universityn
  • Satoh Masahiko
    Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Universityn

Search this article

Abstract

<p>Cadmium (Cd) is a toxic heavy metal, long-term exposure to which causes renal damage associated with disruption in gene expression. Transcription factors whose activities were altered in the kidneys of mice exposed to Cd for 3 months were assessed using protein/DNA-binding assays. Female C57BL/6J mice were exposed to 300 ppm Cd in the diet for 3 months. Nuclear extracts of kidney were used for protein/DNA-binding assays. The concentration of Cd was approximately 100 ppm in mouse kidney, a level that did not induce renal toxicity. Among the 345 transcription factors evaluated, five transcription factors showed over a two-fold increase in their activities and 14 transcription factors showed a half-fold change in their activities after Cd exposure. These findings may provide new information about the causative transcription factors associated with Cd renal toxicity.</p>

Journal

Citations (1)*help

See more

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top