Anti-glomerular Basement Membrane Glomerulonephritis During the First Trimester of Pregnancy
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- Kai Hirayasu
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Usui Joichi
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Tawara Takashi
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Takahashi-Kobayashi Mayumi
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Ishii Ryota
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Tsunoda Ryoya
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Fujita Akiko
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Nagai Kei
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Kaneko Shuzo
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Morito Naoki
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Saito Chie
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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- Hamada Hiromi
- Division of Clinical Medicine, Department of Obstetrics & Gynecology, Faculty of Medicine, University of Tsukuba, Japan
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- Yamagata Kunihiro
- Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
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Abstract
<p>A 28-year-old woman was admitted during the eighth week of her pregnancy because her clinical course was consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) were positive, and the anti-GBM Ab titer being extremely high. She was treated with hemodialysis, plasma exchange and prednisolone. She survived the illness; however, neither the fetus nor her kidney function could be rescued. She had human leukocyte antigen (HLA)-DRB1*1502:01, which differs from the DRB1*1501 associated with anti-GBM GN. When patients have particular symptoms, we should check the urine and serum creatinine to exclude RPGN, even in cases of pregnancy. </p>
Journal
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- Internal Medicine
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Internal Medicine 60 (5), 765-770, 2021-03-01
The Japanese Society of Internal Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390568772521386112
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- NII Article ID
- 130007993548
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- HANDLE
- 2241/0002003841
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- PubMed
- 32999239
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed