Exosome miR-501-3p Elevation Contributes to Progression of Vascular Stiffness

DOI Web Site 参考文献23件 オープンアクセス
  • Toyama Kensuke
    Department of Pharmacology, Ehime University Graduate School of Medicine
  • Igase Michiya
    Department of Anti-aging Medicine, Ehime University Graduate School of Medicine
  • Spin Joshua M.
    VA Palo Alto Health Care System Division of Cardiovascular Medicine, Stanford University School of Medicine
  • Abe Yasunori
    Department of Pharmacology, Ehime University Graduate School of Medicine
  • Javkhlant Amarsanaa
    Department of Pharmacology, Ehime University Graduate School of Medicine
  • Okada Yoko
    Department of Anti-aging Medicine, Ehime University Graduate School of Medicine
  • Wagenhäuser Markus U.
    Department of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University
  • Schelzig Hubert
    Department of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University
  • Tsao Philip S.
    VA Palo Alto Health Care System Division of Cardiovascular Medicine, Stanford University School of Medicine
  • Mogi Masaki
    Department of Pharmacology, Ehime University Graduate School of Medicine

この論文をさがす

抄録

<p>Background:Tight junction (TJ) disruption and dysfunction are involved in the progression of arteriosclerosis. miR-501-3p regulates endothelial TJ protein-1, resulting in TJ disruption. Because exosomal microRNAs can travel to distant tissues and influence cell behavior, patients with elevated miR-501-3p may experience accelerated vascular disease progression secondary to miR-501-3p-induced reductions in TJ. This study investigated whether plasma exosome miR-501-3p levels are associated with vascular stiffness, an indicator for arteriosclerotic changes.</p><p>Methods and Results:Fifty-one subjects (mean [±SD] age 70±8 years, 37% male) enrolled in a medical checkup program were recruited to the study. Brachial-ankle arterial pulse wave velocity (baPWV) and plasma exosome miR-501-3p expression were measured. Patients were divided into 2 groups depending on whether their miR-501-3p ∆Ctvalues were above (“High”; n=24) or below (“Low”; n=27) the cut-off levels determined by receiver operating characteristic (ROC) curve analysis. Median (interquartile range) baPWV levels were significantly higher in the miR-501-3p High than Low group (1,664 [1,496–1,859] vs. 1,450 [1,353–1,686] cm/s, respectively; P<0.05). Multivariate logistic regression analysis showed a significant association between increased baPWV and High miR-501-3p expression (odds ratio 4.66). At follow-up visits (mean 62 months later), baPWV remained significantly higher in the miR-501-3p High than Low group (1,830 [1,624–2,056] vs. 1,620 [1,377–1,816] cm/s, respectively; P<0.05).</p><p>Conclusions:High expression levels of exosome miR-501-3p contribute to arteriosclerotic changes.</p>

収録刊行物

  • Circulation Reports

    Circulation Reports 3 (3), 170-177, 2021-03-10

    一般社団法人 日本循環器学会

参考文献 (23)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ