持続痛と睡眠障害の相互連関機構の解析

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  • Two-way association between sleep disturbance and persistent pain

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<p>Sleep disturbance is one of the most common health problems associated with pain. Patients with chronic pain of different etiologies report sleep problems and these complaints are closely associated with the severity of their pain. Additionally, changes in sleep architecture, such as poor sleep quality, can be associated with an increased likelihood of developing painful conditions. However, the association between chronic insomnia and persistent pain has not yet been fully elucidated. In this study, we investigated whether sleep dysregulation could be caused under a condition of persistent pain. We used a mouse model of neuropathic pain induced by partial sciatic nerve ligation. Vigilance state was divided into three stages, wakefulness, rapid eye movement (REM), and non-REM sleep, according to EEG and EMG recordings. First, we confirmed that sciatic nerve ligation caused long-lasting thermal hyperalgesia and tactile allodynia in mice. Under these conditions, we clarified a significant increase in the duration of wakefulness and a significant decrease in the duration of non-REM sleep. We plan to analyze whether sleep loss could aggravate pain-related behaviors.</p>

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